Huntington's disease
Three cUHDRS components include a spoken task
Stroop Word Reading is read aloud, the motor score carries a dysarthria item, and the Symbol Digit Modalities Test has an oral form. All are scored only at visits. A short recording adds a reading between visits.
Where the reading lands
From the cUHDRS to the spoken components
The UHDRS components that include speech.
The scale
Dysarthria item · Stroop Word Reading · SDMT
The three UHDRS components scored from what the participant says.
The reading
Between scheduled visits
A reading of the speech and language domains those tasks capture.
In practice
Short spoken tasks, mapped to the cUHDRS spoken components
The tasks
Customised to your cohort
For example: spontaneous speech, reading aloud, Stroop Word Reading and the oral SDMT. Tasks and their number are set for each cohort.
Where
At home or in clinic
On the participant's own device, with an automatic quality check at capture.
The output
Between scheduled visits
A reading of the speech and language domains the cUHDRS spoken tasks capture, at every session, followed between visits.
In the trial
Built for real‑world clinical trials
Objective and automated
The same scoring everywhere
Every site and every visit is scored the same way, with no rater in the loop.
On the trial's scale
Mapped to the cUHDRS
Readings on the spoken components: dysarthria item, Stroop Word Reading and SDMT.
Robust
Limits drift when processing changes
Recalibrated from the recordings when on-device processing changes. How it works
Patient-centric
A couple of minutes at home
On the participant's own phone, tablet or computer, between scheduled visits.
Transparent and trackable
Visible per session
Completion, recording quality and versions are logged with every session.
Integrated
No new visit, no new rater
Runs on the Cephalgo platform alongside the assessments the study already runs.
Evidence
Validation following DiMe V3
Following the Digital Medicine Society’s V3 framework.
Clinical validation
From the premanifest stage
Speech and language measures separated premanifest gene carriers from controls in an independent cohort.
White paper
Speech-Based Analysis in Huntington's Disease
Request the white paper
Contact
Where would speech sit in your next HD protocol?
Whether recordings were kept, and what the next protocol measures.
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