Speech domains, mapped by indication
A few minutes of speech carry three domains: cognitive, motor‑speech, and verbal output and content. The map shows which ones each indication uses.
Where speech comes from
Speaking draws on the brain, the breath, the voice and the muscles of the mouth at once. Each leaves its own trace in the recording.
Brain
Plans what is said, finds the words and sets the timing.
Breath
Drives each phrase; changes show in phrase length and pauses.
Vocal folds
Produce the voice; changes show in pitch and voice quality.
Lips, tongue and jaw
Shape each sound; changes show in articulation and speech rate.
Cognitive, motor‑speech, and verbal output and content
One pipeline extracts the speech features in every indication; each reading sits beside the scale that indication’s trials use.
Our pipelineCognitive
How the words are found and what they mean: memory, word-finding and semantic content. Read from picture description, narrative recall, verbal fluency, reading aloud and conversation.
- Memory
- Word-finding
- Verbal fluency
- Semantic content
- Reading speed
Motor-speech
How the sounds are made: breath, voice, articulation and timing. Read from free speech, reading aloud, sustained vowels and syllable repetition, as the protocol sets.
- Articulation
- Prosody
- Speech timing
- Voice quality
- Speech rate
- Phonation
- Respiratory support
Verbal output and content
How much is said, how quickly replies come and which words are chosen. Read from conversation, recorded rating interviews and short home recordings.
- Verbal output
- Response latency
- Lexical content
The domains read in each indication
Each row is one indication: the scale its readings sit beside and the domains they use. Recorded rating interviews also get flags per rater and per site. Trial QC ›
Scopes and deliverables| Indication | Cognitive | Motor-speech | Verbal output and content |
|---|---|---|---|
| Alzheimer’s diseaseMMSE or MoCA; rater checks on CDR |
|
| Not used |
| Parkinson’s diseaseMDS‑UPDRS item 2.1 (Speech) | Not used |
| Not used |
| Huntington’s diseaseStroop Word Reading (cUHDRS) |
|
| Not used |
| ALSALSFRS‑R speech item | Not used |
| Not used |
| DM1 and neuromuscularMDHI communication subscale, FVC or bulbar items | Not used |
| Not used |
| Major depressive disorderMADRS or HAM‑D range, for pre‑screening; rater checks on both | Not used |
|
|
| SchizophreniaPANSS negative symptom items; rater checks on PANSS | Not used |
|
|
| Agitation and psychosis in dementiaNPI caregiver interviews | Each recorded NPI interview is checked, with flags per rater and per site. Trial QC › | ||
