ALS
Speech is already scored in the ALSFRS‑R
The ALSFRS‑R speech item is rated at visits. A short recording of sustained vowels and rapid syllable repetition on the participant’s own phone returns the item’s level in between.
Where the reading lands
From the ALSFRS‑R to what Cephalgo reads
The speech item sits in the bulbar subscore. Cephalgo's reading returns that item's level.
The scale
ALSFRS‑R speech item
The speech item in the bulbar subscore.
The reading
Between scheduled visits
The item’s level from a short recording.
In practice
Short spoken tasks, read on the ALSFRS‑R speech item
The tasks
Customised to your cohort
For example: sustained vowels and rapid syllable repetition. Tasks and their number are set for each cohort.
Where
At home or in clinic
On the participant's own device, with an automatic quality check at capture.
The output
Between scheduled visits
A reading on the ALSFRS‑R speech item at every session, followed between visits.
In the trial
Built for real‑world clinical trials
Objective and automated
The same scoring everywhere
Every site and every visit is scored the same way, with no rater in the loop.
On the trial's scale
Readings on the ALSFRS‑R speech item
Each reading lands on the scale the protocol already carries.
Robust
Limits drift when processing changes
Recalibrated from the recordings when on-device processing changes. How it works
Patient-centric
A couple of minutes at home
On the participant's own phone, tablet or computer, between scheduled visits.
Transparent and trackable
Visible per session
Completion, recording quality and versions are logged with every session.
Integrated
No new visit, no new rater
Runs on the Cephalgo platform alongside the assessments the study already runs.
Evidence
Validation following DiMe V3
Following the Digital Medicine Society’s V3 framework.
Clinical validation
ALSFRS‑R speech item
The reading was evaluated against the neurologist-assigned level on held‑out data.
White paper
Speech-Based Grading and Prediction of the ALSFRS‑R Speech Item in ALS
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Contact
Where is your next ALS protocol going?
Which items your team expects to move first, and how much they vary between visits.
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